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Steven M. Greenberg, MD, PhD

Steven M Greenberg, MD, PHD

Titles and Contact Information

Co-Director of Neurology Clinical Trials Unit

Professor of Neurology, Harvard Medical School

Appointments: 617.724.1874 Memory Disorders Unit || 617.726.4218 Stroke Unit
Fax Number: 617.726.5346

Affiliations and Profiles

  • The Partners Program of Excellence in Alzheimer's and Other Neurodegenerative Diseases
    [Clinical/Research Faculty]

Clinical Interests

  • Cerebral Amyloid Angiopathy (CAA)
  • Cerebral Hemorrhage
  • Dementia
  • General Neurology
  • Stroke

Clinical Background

1988 MD Degree Columbia University
College of
1992 Residency Massachusetts General Hospital
1994 Fellowship Brigham and Women's Hospital
1994 Board Certification Neurology


Johnson KA, Gregas M, Becker JA, Kinnecom C, Salat DH, Moran EK, Smith EE, Rosand J, Rentz DM, Klunk WE, Mathis CA, Price JC, Dekosky ST, Fischman AJ, Greenberg SM
Imaging of amyloid burden and distribution in cerebral amyloid angiopathy.
Ann Neurol. 2007 Sep ; 62 (3): 229-34

Levine JM, Snider R, Finkelstein D, Gurol ME, Chanderraj R, Smith EE, Greenberg SM, Rosand J
Early edema in warfarin-related intracerebral hemorrhage.
Neurocrit Care. 2007 ; 7 (1): 58-63

Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C
Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy.
Brain. 2007 Sep ; 130 (Pt 9): 2310-9

Gudbjartsson DF, Arnar DO, Helgadottir A, Gretarsdottir S, Holm H, Sigurdsson A, Jonasdottir A, Baker A, Thorleifsson G, Kristjansson K, Palsson A, Blondal T, Sulem P, Backman VM, Hardarson GA, Palsdottir E, Helgason A, Sigurjonsdottir R, Sverrisson JT, Kostulas K, Ng MC, Baum L, So WY, Wong KS, Chan JC, Furie KL, Greenberg SM, Sale M, Kelly P, MacRae CA, Smith EE, Rosand J, Hillert J, Ma RC, Ellinor PT, Thorgeirsson G, Gulcher JR, Kong A, Thorsteinsdottir U, Stefansson K
Variants conferring risk of atrial fibrillation on chromosome 4q25.
Nature. 2007 Jul 19; 448 (7151): 353-7

Kinnecom C, Lev MH, Wendell L, Smith EE, Rosand J, Frosch MP, Greenberg SM
Course of cerebral amyloid angiopathy-related inflammation.
Neurology. 2007 Apr 24; 68 (17): 1411-6

Goldstein JN, Fazen LE, Snider R, Schwab K, Greenberg SM, Smith EE, Lev MH, Rosand J
Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage.
Neurology. 2007 Mar 20; 68 (12): 889-94

Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, Dekosky ST, Greenberg SM, Hyman BT, Growdon JH
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.
Arch Neurol. 2007 Mar ; 64 (3): 431-4

Greenberg SM, Parisi JE, Keegan BM
A 63-year-old man with headaches and behavioral deterioration.
Neurology. 2007 Mar 6; 68 (10): 782-7

Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP
Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging.
J Neurosci. 2007 Feb 21; 27 (8): 1973-80

Nandigam RN, Chen YW, Gurol ME, Rosand J, Greenberg SM, Smith EE
Validation of intracranial area as a surrogate measure of intracranial volume when using clinical MRI.
J Neuroimaging. 2007 Jan ; 17 (1): 74-7

Greenberg SM, Rosand J, Schneider AT, Creed Pettigrew L, Gandy SE, Rovner B, Fitzsimmons BF, Smith EE, Edip Gurol M, Schwab K, Laurin J, Garceau D
A phase 2 study of tramiprosate for cerebral amyloid angiopathy.
Alzheimer Dis Assoc Disord. ; 20 (4): 269-74

Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP
Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease.
Neurobiol Dis. 2006 Dec ; 24 (3): 516-24

Greenberg SM
Is "compassionate use" compassionate?: rFVIIa for intracerebral hemorrhage.
Neurology. 2006 Sep 26; 67 (6): 934-5

Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH
Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes.
Brain Res. 2006 Sep 21; 1111 (1): 222-6

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The MGH Neurology Department placed 4th in US News Neurology / NeuroSurgery rankings for 2013-14.

Educational Video

Still from the Stroke Evaluation simulation

This video simulation of an Emergency stroke evaluation illustrates the care of patients with acute stroke by the MGH Acute Stroke team.