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Karen L. Furie, M.D., MPH

Karen L. Furie, M.D., MPH

Titles and Contact Information

Director, Stroke Service, Massachusetts General Hospital

Assistant in Neurology

Director, Stroke Prevention Clinic, Massachusetts General Hospital

Appointments: 617.726.8459
Fax Number: 617.643.3939

Affiliations and Profiles

Clinical Interests

  • Stroke
  • TIAS
  • Cerebrovascular Disorders
  • Neurosonology

Clinical Background

1990 M.D. Degree Brown University School of Medicine
1994 Residency Rhode Island Hospital
1995 Fellowship Brown University
Cerebrovascular Disease
1996 Harvard School of Public Health
Masters in Public Health


Stein J, Shafqat S, Doherty D, Frates EP, Furie KL
Family member knowledge and expectations for functional recovery after stroke.
Am J Phys Med Rehabil 2003; 82: 169-74.. ; ():

Kelly PJ, Furie KL, Kistler JP, Barron M, Picard EH, Mandell R, Shih VE
Stroke in young patients with hyperhomocysteinemia due to cystathionine beta synthase deficiency.
Neurology 2003; 60: 275-9.. ; ():

Kelly PJ, Shih VE, Kistler JP, Barron M, Lee H, Mandell R, Furie KL
Low vitamin B6 but not homocysteine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain supplementation.
Stroke 2003; 34:e51-4.. ; ():

Stein J, Shafqat S, Doherty D, Frates EP, Furie KL
Patient knowledge and expectations for functional recovery after stroke.
Am J Phys Med Rehabil. 2003; 82: 591-6.. ; ():

Kelly PJ, Furie KL, Shafqat S, Rallis N, Chang Y, Stein J
Functional recovery following rehabilitation after hemorrhagic and ischemic stroke.
Arch PM&R 2003; 84: 968-72.. ; ():

Kelly PJ, Stein J, Shafqat S, Doherty D, Chang Y, Kurina A, Furie KL
Functional recovery after cerebellar stroke.
Stroke 2001; 32:530-4.. ; ():

Gleason SG, Furie KL, Lev M, O'Donnell J, McMahon PM, Beinfeld MT, Halpern E, Mullins M, Harris G, Koroshetz WJ, Gazelle GS
Potential Influence of Acute CT imaging on inpatient costs in ischemic stroke.
Academic Radiology 2001; 8:955-64.. ; ():

Mohr JP, Thompson JL, Levin B, Sacco RL, Furie KL, Kistler JP, Albers GW, Pettigrew LC, Adams HP Jr, Jackson CM, Pullicino P
A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke.
N Engl J Med 2001; 345:1444-51.. ; ():

Kelly PJ, Rosand J, Plomaritoglou A, Kistler JP, Shih VE, Silveira S, Plomaritoglou A, Furie KL
Homocysteine, MTHFR 677CàT polymorphism, and risk of ischemic stroke: results of a meta-analysis.
Neurology 2002; 59: 529-36.. ; ():

Ay H, Oliveira-Filho J, Buonanno FS, Schafer PW, Barron M, Furie KL, Chang YC, Schwamm LH, Gonzalez RG, Koroshetz WJ
Footprints of transient ischemic attacks: a diffusion-weighted MRI study.
Cerebrovascular Dis 2002; 14:177-86.. ; ():

Kelly PJ, Barron M, Furie KL
Hyperhomocysteinemia, MTHFR C677CàT polymorphism, and stroke.
Stroke 2002; 33: 1452-3.. ; ():

Glantz MJ, Cole BF, Friedberg MH, Lathi E, Furie KL, Akerley W, Wahlberg L, Lekos A, Louis S
A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors.
Neurology 1996; 46: 985-91.. ; ():

Suwanwela N, Can U, Furie KL, Southern JF, Mcdonald NR, Ogilvy CS, Hansen CJ, Buonanno FS, Abbott WM, Koroshetz WJ, Kistler JP
Carotid Doppler ultrasound criteria for internal carotid artery stenosis based on residual lumen diameter calculated from en bloc carotid endarterectomy specimens.
Stroke 1996; 27: 1965-69.. ; ():

Wilterdink JL, Feldmann E, Furie KL, Bragoni M, Benavides J
"A transcranial Doppler ultrasound battery reliably identifies severe internal carotid artery stenosis,"
Stroke 1997, 28;133-6.. ; ():

Can U, Furie KL, Suwanwela N, Southern JF, Macdonald NR, Ogilvy CS, Buonanno FS, Koroshetz WJ, Kistler JP
Transcranial Doppler ultrasound criteria for internal carotid artery stenosis based on residual lumen diameter calculated from en bloc carotid endarterectomy specimens.
Stroke 1997; 28: 1966-71.. ; ():

Furie KL, Wilterdink JL
The epidemiology of stroke: a focus on Rhode Island.
Medicine and Health Rhode Island 1997; 80: 142-5.. ; ():

Furie KL
The WARSS, APASS, HAS and Genesis Study Groups*. The feasibility of a collaborative double-blind study using an anticoagulant.
Cerebrovasc Dis 1997; 7:100-12.. ; ():

Ay H, Furie KL, Koroshetz W
Diffusion-weighted MRI characterizes the ischemic lesion in transient global amnesia.
Neurology 1998; 51: 901-03.. ; ():

Wilterdink JL, Furie KL, Easton JD
Cardiac evaluation of stroke patients.
Neurology 1998; 51 Suppl 3: 23-6.. ; ():

O'Donnell HC, Rosand J, Knudsen KA, Furie KL, Segal AZ, Chiu RI, Ikeda D, Greenberg SM
Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage.
N Engl J Med 2000; 342: 240-45.. ; ():

Furie KL
Antiphospholipid Antibodies in Stroke Study Group*. Anticardiolipin antibodies are an independent risk factor for first ischemic stroke.
Neurology 1993; 43: 2069-73.. ; ():

Ickenstein GW, Kelly PJ, Furie KL, Ambrosi D, Rallis N, Goldstein R, Horick N, Stein J
Predictors of feeding gastrostomy tube removal in stroke patients with dysphagia.
J Stroke Cerebrovasc Dis. ; 12 (4): 169-174

Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG
A Computerized Algorithm for Etiologic Classification of Ischemic Stroke. The Causative Classification of Stroke System.
Stroke. 2007 Sep 27; ():

Furie KL, Smith EE
Metabolic syndrome: a target for preventing leukoaraiosis and age-related dementia?
Neurology. 2007 Sep 4; 69 (10): 951-2

Phillips SJ, Dai D, Mitnitski A, Gubitz GJ, Johnston KC, Koroshetz WJ, Furie KL, Black S, Heiselman DE,
Clinical diagnosis of lacunar stroke in the first 6 hours after symptom onset: analysis of data from the glycine antagonist in neuroprotection (GAIN) Americas trial.
Stroke. 2007 Oct ; 38 (10): 2706-11

Glymour MM, Berkman LF, Ertel KA, Fay ME, Glass TA, Furie KL
Lesion characteristics, NIH stroke scale, and functional recovery after stroke.
Am J Phys Med Rehabil. 2007 Sep ; 86 (9): 725-33

Gudbjartsson DF, Arnar DO, Helgadottir A, Gretarsdottir S, Holm H, Sigurdsson A, Jonasdottir A, Baker A, Thorleifsson G, Kristjansson K, Palsson A, Blondal T, Sulem P, Backman VM, Hardarson GA, Palsdottir E, Helgason A, Sigurjonsdottir R, Sverrisson JT, Kostulas K, Ng MC, Baum L, So WY, Wong KS, Chan JC, Furie KL, Greenberg SM, Sale M, Kelly P, MacRae CA, Smith EE, Rosand J, Hillert J, Ma RC, Ellinor PT, Thorgeirsson G, Gulcher JR, Kong A, Thorsteinsdottir U, Stefansson K
Variants conferring risk of atrial fibrillation on chromosome 4q25.
Nature. 2007 Jul 19; 448 (7151): 353-7

Camargo EC, Furie KL, Singhal AB, Roccatagliata L, Cunnane ME, Halpern EF, Harris GJ, Smith WS, Gonzalez RG, Koroshetz WJ, Lev MH
Acute brain infarct: detection and delineation with CT angiographic source images versus nonenhanced CT scans.
Radiology. 2007 Aug ; 244 (2): 541-8

Howard VJ, Furie KL, Wang CH, Sides EG, Toole JF
The changing risk factor profile of participants enrolled in a secondary stroke prevention trial: Vitamin intervention for stroke prevention.
Neuroepidemiology. 2006 ; 27 (4): 222-9

Furie KL
Ask the doctor. For the last few years, I have been experiencing what I think are mini-strokes. The first time it happened, I lost the sight in one eye for about a minutes. Sometimes the vision in both eyes gets blurred for a few minutes. A few weeks ago I could not think of the word "battery" while talking with a friend. Otherwise, I am a healthy 77-year-old who exercises, isn't overweight, and doesn't smoke. My doctor hasn't suggested any tests of courses of action. Can you?
Harv Heart Lett. 2006 Jun ; 16 (10): 8

Takaya N, Cai J, Ferguson MS, Yarnykh VL, Chu B, Saam T, Polissar NL, Sherwood J, Cury RC, Anders RJ, Broschat KO, Hinton D, Furie KL, Hatsukami TS, Yuan C
Intra- and interreader reproducibility of magnetic resonance imaging for quantifying the lipid-rich necrotic core is improved with gadolinium contrast enhancement.
J Magn Reson Imaging. 2006 Jul ; 24 (1): 203-10

Ning M, Furie KL, Koroshetz WJ, Lee H, Barron M, Lederer M, Wang X, Zhu M, Sorensen AG, Lo EH, Kelly PJ
Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke.
Neurology. 2006 May 23; 66 (10): 1550-5

Furie KL, Kelly PJ
Homocyst(e)ine and stroke.
Semin Neurol. 2006 Feb ; 26 (1): 24-32

Hinton DP, Cury RC, Chan RC, Wald LL, Sherwood JB, Furie KL, Pitts JT, Schmitt F
Bright and black blood imaging of the carotid bifurcation at 3.0T.
Eur J Radiol. 2006 Mar ; 57 (3): 403-11

Cury RC, Houser SL, Furie KL, Stone JR, Ogilvy CS, Sherwood JB, Muller JE, Brady TJ, Hinton DP
Vulnerable plaque detection by 3.0 tesla magnetic resonance imaging.
Invest Radiol. 2006 Feb ; 41 (2): 112-5

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ
An evidence-based causative classification system for acute ischemic stroke.
Ann Neurol. 2005 Nov ; 58 (5): 688-97

Cronin S, Furie KL, Kelly PJ
Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis.
Stroke. 2005 Jul ; 36 (7): 1581-7

Ning MM, Smirnakis S, Furie KL, Sheen VL
Adult acute disseminated encephalomyelitis associated with poststreptococcal infection.
J Clin Neurosci. 2005 Apr ; 12 (3): 298-300

Wang X, Tsuji K, Lee SR, Ning M, Furie KL, Buchan AM, Lo EH
Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke.
Stroke. 2004 Nov ; 35 (11 Suppl 1): 2726-30

Furie KL, Rosenberg R, Thompson JL, Bauer K, Mohr JP, Rosner B, Sciacca R, Barzegar S, Thornell B, Costigan T, Kistler JP
Thrombin generation in non-cardioembolic stroke subtypes: the Hemostatic System Activation Study.
Neurology. 2004 Sep 14; 63 (5): 777-84

Shafqat S, Kelly PJ, Furie KL
Holter monitoring in the diagnosis of stroke mechanism.
Intern Med J. 2004 Jun ; 34 (6): 305-9

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In the News

The MGH Neurology Department placed 4th in US News Neurology / NeuroSurgery rankings for 2013-14.

Educational Video

Still from the Stroke Evaluation simulation

This video simulation of an Emergency stroke evaluation illustrates the care of patients with acute stroke by the MGH Acute Stroke team.