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Seth P. Finklestein, MD

Seth Paul Finklestein, MD

Title and Contact Information

Associate Neurologist

Appointments: (617) 726-8459
Fax Number: (617) 724-1480

Affiliations and Profiles

Clinical Interests

  • Stroke
  • Head Injury
  • Spinal Cord Injury
  • Other Neurological Diseases

Clinical Background

1974 MD Degree Harvard Medical School
1978 Residency University of California San Francisco Medical Center
1979 Board Certification Neurology
1980 Fellowship Massachusetts General Hospital
Stroke Fellow
1984 Fellowship McLean Hospital, Belmont, MA


Feuerstein GZ, Zaleska MM, Krams M, Wang X, Day M, Rutkowski JL, Finklestein SP, Pangalos MN, Poole M, Stiles GL, Ruffolo RR, Walsh FL
Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke.
J Cereb Blood Flow Metab. 2007 Jun 20; ():

Ren J, Sietsma D, Qiu S, Moessler H, Finklestein SP
Cerebrolysin enhances functional recovery following focal cerebral infarction in rats.
Restor Neurol Neurosci. 2007 ; 25 (1): 25-31

Cramer SC, Koroshetz WJ, Finklestein SP
The case for modality-specific outcome measures in clinical trials of stroke recovery-promoting agents.
Stroke. 2007 Apr ; 38 (4): 1393-5

Romero JR, Babikian VL, Katz DI, Finklestein SP
Neuroprotection and stroke rehabilitation: modulation and enhancement of recovery.
Behav Neurol. 2006 ; 17 (1): 17-24

Berry D, Ren J, Kwan CP, Sietsma DK, Sasisekharan R, Finklestein SP
Dimeric fibroblast growth factor-2 enhances functional recovery after focal cerebral ischemia.
Restor Neurol Neurosci. 2005 ; 23 (3-4): 251-6

Ren JM, Finklestein SP
Growth factor treatment of stroke.
Curr Drug Targets CNS Neurol Disord. 2005 Apr ; 4 (2): 121-5

Kong KY, Ren J, Kraus M, Finklestein SP, Brown RH
Human umbilical cord blood cells differentiate into muscle in sjl muscular dystrophy mice.
Stem Cells. 2004 ; 22 (6): 981-93

Wada K, Sugimori H, Bhide PG, Moskowitz MA, Finklestein SP
Effect of basic fibroblast growth factor treatment on brain progenitor cells after permanent focal ischemia in rats.
Stroke. 2003 Nov ; 34 (11): 2722-8

Cairns K, Finklestein SP
Growth factors and stem cells as treatments for stroke recovery.
Phys Med Rehabil Clin N Am. 2003 Feb ; 14 (1 Suppl): S135-42

Dijkhuizen RM, Singhal AB, Mandeville JB, Wu O, Halpern EF, Finklestein SP, Rosen BR, Lo EH
Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study.
J Neurosci. 2003 Jan 15; 23 (2): 510-7

Schaechter JD, Kraft E, Hilliard TS, Dijkhuizen RM, Benner T, Finklestein SP, Rosen BR, Cramer SC
Motor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary study.
Neurorehabil Neural Repair. 2002 Dec ; 16 (4): 326-38

Cramer SC, Weisskoff RM, Schaechter JD, Nelles G, Foley M, Finklestein SP, Rosen BR
Motor cortex activation is related to force of squeezing.
Hum Brain Mapp. 2002 Aug ; 16 (4): 197-205

Dijkhuizen RM, Ren J, Mandeville JB, Wu O, Ozdag FM, Moskowitz MA, Rosen BR, Finklestein SP
Functional magnetic resonance imaging of reorganization in rat brain after stroke.
Proc Natl Acad Sci U S A. 2001 Oct 23; 98 (22): 12766-71

Cramer SC, Nelles G, Schaechter JD, Kaplan JD, Finklestein SP, Rosen BR
A functional MRI study of three motor tasks in the evaluation of stroke recovery.
Neurorehabil Neural Repair. 2001 ; 15 (1): 1-8

Ay I, Sugimori H, Finklestein SP
Intravenous basic fibroblast growth factor (bFGF) decreases DNA fragmentation and prevents downregulation of Bcl-2 expression in the ischemic brain following middle cerebral artery occlusion in rats.
Brain Res Mol Brain Res. 2001 Feb 19; 87 (1): 71-80

Sugimori H, Speller H, Finklestein SP
Intravenous basic fibroblast growth factor produces a persistent reduction in infarct volume following permanent focal ischemia in rats.
Neurosci Lett. 2001 Mar 2; 300 (1): 13-6

Cramer SC, Moore CI, Finklestein SP, Rosen BR
A pilot study of somatotopic mapping after cortical infarct.
Stroke. 2000 Mar ; 31 (3): 668-71

Ren J, Kaplan PL, Charette MF, Speller H, Finklestein SP
Time window of intracisternal osteogenic protein-1 in enhancing functional recovery after stroke.
Neuropharmacology. 2000 Mar 3; 39 (5): 860-5

Upton-Rice MN, Cudkowicz ME, Warren L, Mathew RK, Ren JM, Finklestein SP, Brown RH
Basic fibroblast growth factor does not prolong survival in a transgenic model of familial amyotrophic lateral sclerosis.
Ann Neurol. 1999 Dec ; 46 (6): 934

Kawamata T, Ren J, Cha JH, Finklestein SP
Intracisternal antisense oligonucleotide to growth associated protein-43 blocks the recovery-promoting effects of basic fibroblast growth factor after focal stroke.
Exp Neurol. 1999 Jul ; 158 (1): 89-96

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In the News

The MGH Neurology Department placed 4th in US News Neurology / NeuroSurgery rankings for 2013-14.

Educational Video

Still from the Stroke Evaluation simulation

This video simulation of an Emergency stroke evaluation illustrates the care of patients with acute stroke by the MGH Acute Stroke team.