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Natalia S. Rost, M.D., M.P.H.

Rost, Natalia S,M.D.

Titles and Contact Information

Associate Director, Acute Stroke Services, Massachusetts General Hospital

Assistant in Neurology, Massachusetts General Hospital, Department of Neurology

Assistant Professor of Neurology, Harvard Medical School

Appointments: 617.726.8459
Fax Number: 617.726.5043

Affiliations and Profiles

Clinical Interests

  • Acute Stroke and Intracerebral Hemorrhage
  • Clinical Trials and Outcomes in Stroke
  • Genetics of Stroke and Other Cerebrovascular Disorders
  • Neuroimaging

Clinical Background

1998 - 2002 MD Degree Boston University
School of Medicine
2002 - 2003 Residency Massachusetts General Hospital
Internal Medicine
2003 - 2006 Residency Massachusetts General Hospital and Brigham and Women's Hospital
2006 - 2007 Fellowship Massachusetts General Hospital and Brigham and Women's Hospital
Vascular and Critical Care Neurology
2008 - 2011 M.P.H Degree Harvard School of Public Health


Russian (fluent)
French (conversational)


Biffi A, Cortellini L, Nearnberg CM, Ayres AM, Schwab K, Gilson AJ, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J
Body Mass Index and Etiology of Intracerebral Hemorrhage.
Stroke. 2011 Jul 21; ():

Crandall KM, Rost NS, Sheth KN
Prognosis in intracerebral hemorrhage.
Rev Neurol Dis. 2011 ; 8 (1-2): 23-9

Arsava EM, Bayrlee A, Vangel M, Rost NS, Rosand J, Furie KL, Sorensen AG, Ay H
Severity of leukoaraiosis determines clinical phenotype after brain infarction.
Neurology. 2011 Jul 5; 77 (1): 55-61

Biffi A, Anderson CD, Jagiella JM, Schmidt H, Kissela B, Hansen BM, Jimenez-Conde J, Pires CR, Ayres AM, Schwab K, Cortellini L, Pera J, Urbanik A, Romero JM, Rost NS, Goldstein JN, Viswanathan A, Pichler A, Enzinger C, Rabionet R, Norrving B, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Broderick JP, Greenberg SM, Roquer J, Lindgren A, Slowik A, Schmidt R, Woo D, Rosand J,
APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study.
Lancet Neurol. 2011 Aug ; 10 (8): 702-709

Biffi A, Devan WJ, Anderson CD, Ayres AM, Schwab K, Cortellini L, Viswanathan A, Rost NS, Smith EE, Goldstein JN, Greenberg SM, Rosand J
Statin use and outcome after intracerebral hemorrhage: case-control study and meta-analysis.
Neurology. 2011 May 3; 76 (18): 1581-8

Biffi A, Devan WJ, Anderson CD, Cortellini L, Furie KL, Rosand J, Rost NS
Statin treatment and functional outcome after ischemic stroke: case-control and meta-analysis.
Stroke. 2011 May ; 42 (5): 1314-9

Sheth KN, Gilson AJ, Chang Y, Kumar MA, Rahman RM, Rost NS, Schwab K, Cortellini L, Goldstein JN, Smith EE, Greenberg SM, Rosand J
Packed Red Blood Cell Transfusion and Decreased Mortality in Intracerebral Hemorrhage.
Neurosurgery. 2011 May ; 68 (5): 1286-1292

Anderson CD, Nalls MA, Biffi A, Rost NS, Greenberg SM, Singleton AB, Meschia JF, Rosand J
The effect of survival bias on case-control genetic association studies of highly lethal diseases.
Circ Cardiovasc Genet. 2011 Apr ; 4 (2): 188-96

Biffi A, Sonni A, Anderson CD, Kissela B, Jagiella JM, Schmidt H, Jimenez-Conde J, Hansen BM, Fernandez-Cadenas I, Cortellini L, Ayres A, Schwab K, Juchniewicz K, Urbanik A, Rost NS, Viswanathan A, Seifert-Held T, Stoegerer EM, Tomás M, Rabionet R, Estivill X, Brown DL, Silliman SL, Selim M, Worrall BB, Meschia JF, Montaner J, Lindgren A, Roquer J, Schmidt R, Greenberg SM, Slowik A, Broderick JP, Woo D, Rosand J,
Variants at APOE influence risk of deep and lobar intracerebral hemorrhage.
Ann Neurol. 2010 Dec ; 68 (6): 934-43

Rost NS, Rahman RM, Biffi A, Smith EE, Kanakis A, Fitzpatrick K, Lima F, Worrall BB, Meschia JF, Brown RD, Brott TG, Sorensen AG, Greenberg SM, Furie KL, Rosand J
White matter hyperintensity volume is increased in small vessel stroke subtypes.
Neurology. 2010 Nov 9; 75 (19): 1670-7

Rost NS, Fitzpatrick K, Biffi A, Kanakis A, Devan W, Anderson CD, Cortellini L, Furie KL, Rosand J
White matter hyperintensity burden and susceptibility to cerebral ischemia.
Stroke. 2010 Dec ; 41 (12): 2807-11

Anderson CD, Biffi A, Rahman R, Ross OA, Jagiella JM, Kissela B, Cole JW, Cortellini L, Rost NS, Cheng YC, Greenberg SM, de Bakker PI, Brown RD, Brott TG, Mitchell BD, Broderick JP, Worrall BB, Furie KL, Kittner SJ, Woo D, Slowik A, Meschia JF, Saxena R, Rosand J,
Common mitochondrial sequence variants in ischemic stroke.
Ann Neurol. 2011 Mar ; 69 (3): 471-80

Thompson BB, Béjot Y, Caso V, Castillo J, Christensen H, Flaherty ML, Foerch C, Ghandehari K, Giroud M, Greenberg SM, Hallevi H, Hemphill JC, Heuschmann P, Juvela S, Kimura K, Myint PK, Nagakane Y, Naritomi H, Passero S, Rodríguez-Yáñez MR, Roquer J, Rosand J, Rost NS, Saloheimo P, Salomaa V, Sivenius J, Sorimachi T, Togha M, Toyoda K, Turaj W, Vemmos KN, Wolfe CD, Woo D, Smith EE
Prior antiplatelet therapy and outcome following intracerebral hemorrhage: a systematic review.
Neurology. 2010 Oct 12; 75 (15): 1333-42

Biffi A, Anderson CD, Nalls MA, Rahman R, Sonni A, Cortellini L, Rost NS, Matarin M, Hernandez DG, Plourde A, de Bakker PI, Ross OA, Greenberg SM, Furie KL, Meschia JF, Singleton AB, Saxena R, Rosand J
Principal-component analysis for assessment of population stratification in mitochondrial medical genetics.
Am J Hum Genet. 2010 Jun 11; 86 (6): 904-17

Edlow BL, Wainger BJ, Frosch MP, Copen WA, Rathmell JP, Rost NS
Posterior circulation stroke after C1-C2 intraarticular facet steroid injection: evidence for diffuse microvascular injury.
Anesthesiology. 2010 Jun ; 112 (6): 1532-5

Rost NS, Rahman R, Sonni S, Kanakis A, Butler C, Massasa E, Cloonan L, Gilson A, Delgado P, Chang Y, Biffi A, Jimenez-Conde J, Besanger A, Silva G, Smith EE, Rosand J, Furie KL
Determinants of white matter hyperintensity volume in patients with acute ischemic stroke.
J Stroke Cerebrovasc Dis. 2010 May ; 19 (3): 230-5

International Stroke Genetics Consortium , Wellcome Trust Case-Control Consortium 2
Failure to validate association between 12p13 variants and ischemic stroke.
N Engl J Med. 2010 Apr 22; 362 (16): 1547-50

Anderson CD, Biffi A, Rost NS, Cortellini L, Furie KL, Rosand J
Chromosome 9p21 in ischemic stroke: population structure and meta-analysis.
Stroke. 2010 Jun ; 41 (6): 1123-31

Jimenez-Conde J, Biffi A, Rahman R, Kanakis A, Butler C, Sonni S, Massasa E, Cloonan L, Gilson A, Capozzo K, Cortellini L, Ois A, Cuadrado-Godia E, Rodriguez-Campello A, Furie KL, Roquer J, Rosand J, Rost NS
Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke.
Stroke. 2010 Mar ; 41 (3): 437-42

Rost NS, Masrur S, Pervez MA, Viswanathan A, Schwamm LH
Unsuspected coagulopathy rarely prevents IV thrombolysis in acute ischemic stroke.
Neurology. 2009 Dec 8; 73 (23): 1957-62

Pervez MA, Silva G, Masrur S, Betensky R, Furie KL, Renzo H, Lima F, Rosenthal E, Rost NS, Viswanathan A, Schwamm LH
Remote Supervision of IV-tPA for Acute Ischemic Stroke by Telemedicine or Telephone Prior to Transfer to a Regional Stroke Center is Feasible and Safe.
Stroke 2009;in press. ; ():

Morrow DA, Scirica BM, Fox KA, Berman G, Strony J, Veltri E, Bonaca MP, Fish P, McCabe CH, Braunwald E, TRA 2(o)P-TIMI 50 Investigators
Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial.
Am Heart J. 2009 Sep ; 158 (3): 335-341.e3

Kimberly WT, Gilson A, Rost NS, Rosand J, Viswanathan A, Smith EE, Greenberg SM
Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy.
Neurology. 2009 Apr 7; 72 (14): 1230-5

Arsava EM, Rahman R, Rosand J, Lu J, Smith EE, Rost NS, Singhal AB, Lev MH, Furie KL, Koroshetz WJ, Sorensen AG, Ay H
Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke.
Neurology. 2009 Apr 21; 72 (16): 1403-10

Kumar MA, Rost NS, Snider RW, Chanderraj R, Greenberg SM, Smith EE, Rosand J
Anemia and hematoma volume in acute intracerebral hemorrhage.
Crit Care Med. 2009 Apr ; 37 (4): 1442-7

Goldstein JN, Fazen LE, Wendell L, Chang Y, Rost NS, Snider R, Schwab K, Chanderraj R, Kabrhel C, Kinnecom C, Fitzmaurice E, Smith EE, Greenberg SM, Rosand J
Risk of thromboembolism following acute intracerebral hemorrhage.
Neurocrit Care. 2009 ; 10 (1): 28-34

Rost NS, Smith EE, Chang Y, Snider RW, Chanderraj R, Schwab K, FitzMaurice E, Wendell L, Goldstein JN, Greenberg SM, Rosand J
Prediction of functional outcome in patients with primary intracerebral hemorrhage: the FUNC score.
Stroke. 2008 Aug ; 39 (8): 2304-9

Rost NS, Greenberg SM, Rosand J
The genetic architecture of intracerebral hemorrhage.
Stroke. 2008 Jul ; 39 (7): 2166-73

FitzMaurice E, Wendell L, Snider R, Schwab K, Chanderraj R, Kinnecom C, Nandigam K, Rost NS, Viswanathan A, Rosand J, Greenberg SM, Smith EE
Effect of statins on intracerebral hemorrhage outcome and recurrence.
Stroke. 2008 Jul ; 39 (7): 2151-4

Rosand J, Bayley N, Rost N, de Bakker PI
Many hypotheses but no replication for the association between PDE4D and stroke.
Nat Genet. 2006 Oct ; 38 (10): 1091-2; author reply 1092-3

Rost NS, Wolf PA, Kase CS, Kelly-Hayes M, Silbershatz H, Massaro JM, D'Agostino RB, Franzblau C, Wilson PW
Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study.
Stroke. 2001 Nov ; 32 (11): 2575-9

Rost NS, Murphy K, Hafer L, Pavao M, Traish AM
Immunochemical analyses of estrogen receptors in human breast tumors by a novel monoclonal estrogen receptor antibody (EVG F9).
Steroids. 2000 Aug ; 65 (8): 429-36

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The MGH Neurology Department placed 4th in US News Neurology / NeuroSurgery rankings for 2013-14.

Educational Video

Still from the Stroke Evaluation simulation

This video simulation of an Emergency stroke evaluation illustrates the care of patients with acute stroke by the MGH Acute Stroke team.