Titles and Contact Information
Associate Director, Acute Stroke Services, Massachusetts General Hospital
Assistant in Neurology, Massachusetts General Hospital, Department of Neurology
Assistant Professor of Neurology, Harvard Medical School
Appointments: 617.726.8459
Fax Number: 617.726.5043
Affiliations and Profiles
Clinical Interests
- Acute Stroke and Intracerebral Hemorrhage
- Clinical Trials and Outcomes in Stroke
- Genetics of Stroke and Other Cerebrovascular Disorders
- Neuroimaging
Clinical Background
1998 - 2002 |
MD Degree
|
Boston University School of Medicine |
2002 - 2003 |
Residency
|
Massachusetts General Hospital Internal Medicine |
2003 - 2006 |
Residency
|
Massachusetts General Hospital and Brigham and Women's Hospital Neurology |
2006 - 2007 |
Fellowship
|
Massachusetts General Hospital and Brigham and Women's Hospital Vascular and Critical Care Neurology |
2008 - 2011 |
M.P.H Degree
|
Harvard School of Public Health
|
Languages
Russian (fluent)
French (conversational)
Articles
Biffi
A, Cortellini
L, Nearnberg
CM, Ayres
AM, Schwab
K, Gilson
AJ, Rost
NS, Goldstein
JN, Viswanathan
A, Greenberg
SM, Rosand
J
Body Mass Index and Etiology of Intracerebral Hemorrhage.
Stroke.
2011
Jul
21;
():
Crandall
KM, Rost
NS, Sheth
KN
Prognosis in intracerebral hemorrhage.
Rev Neurol Dis.
2011
;
8
(1-2):
23-9
Arsava
EM, Bayrlee
A, Vangel
M, Rost
NS, Rosand
J, Furie
KL, Sorensen
AG, Ay
H
Severity of leukoaraiosis determines clinical phenotype after brain infarction.
Neurology.
2011
Jul
5;
77
(1):
55-61
Biffi
A, Anderson
CD, Jagiella
JM, Schmidt
H, Kissela
B, Hansen
BM, Jimenez-Conde
J, Pires
CR, Ayres
AM, Schwab
K, Cortellini
L, Pera
J, Urbanik
A, Romero
JM, Rost
NS, Goldstein
JN, Viswanathan
A, Pichler
A, Enzinger
C, Rabionet
R, Norrving
B, Tirschwell
DL, Selim
M, Brown
DL, Silliman
SL, Worrall
BB, Meschia
JF, Kidwell
CS, Broderick
JP, Greenberg
SM, Roquer
J, Lindgren
A, Slowik
A, Schmidt
R, Woo
D, Rosand
J,
APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study.
Lancet Neurol.
2011
Aug
;
10
(8):
702-709
Biffi
A, Devan
WJ, Anderson
CD, Ayres
AM, Schwab
K, Cortellini
L, Viswanathan
A, Rost
NS, Smith
EE, Goldstein
JN, Greenberg
SM, Rosand
J
Statin use and outcome after intracerebral hemorrhage: case-control study and meta-analysis.
Neurology.
2011
May
3;
76
(18):
1581-8
Biffi
A, Devan
WJ, Anderson
CD, Cortellini
L, Furie
KL, Rosand
J, Rost
NS
Statin treatment and functional outcome after ischemic stroke: case-control and meta-analysis.
Stroke.
2011
May
;
42
(5):
1314-9
Sheth
KN, Gilson
AJ, Chang
Y, Kumar
MA, Rahman
RM, Rost
NS, Schwab
K, Cortellini
L, Goldstein
JN, Smith
EE, Greenberg
SM, Rosand
J
Packed Red Blood Cell Transfusion and Decreased Mortality in Intracerebral Hemorrhage.
Neurosurgery.
2011
May
;
68
(5):
1286-1292
Anderson
CD, Nalls
MA, Biffi
A, Rost
NS, Greenberg
SM, Singleton
AB, Meschia
JF, Rosand
J
The effect of survival bias on case-control genetic association studies of highly lethal diseases.
Circ Cardiovasc Genet.
2011
Apr
;
4
(2):
188-96
Biffi
A, Sonni
A, Anderson
CD, Kissela
B, Jagiella
JM, Schmidt
H, Jimenez-Conde
J, Hansen
BM, Fernandez-Cadenas
I, Cortellini
L, Ayres
A, Schwab
K, Juchniewicz
K, Urbanik
A, Rost
NS, Viswanathan
A, Seifert-Held
T, Stoegerer
EM, Tomás
M, Rabionet
R, Estivill
X, Brown
DL, Silliman
SL, Selim
M, Worrall
BB, Meschia
JF, Montaner
J, Lindgren
A, Roquer
J, Schmidt
R, Greenberg
SM, Slowik
A, Broderick
JP, Woo
D, Rosand
J,
Variants at APOE influence risk of deep and lobar intracerebral hemorrhage.
Ann Neurol.
2010
Dec
;
68
(6):
934-43
Rost
NS, Rahman
RM, Biffi
A, Smith
EE, Kanakis
A, Fitzpatrick
K, Lima
F, Worrall
BB, Meschia
JF, Brown
RD, Brott
TG, Sorensen
AG, Greenberg
SM, Furie
KL, Rosand
J
White matter hyperintensity volume is increased in small vessel stroke subtypes.
Neurology.
2010
Nov
9;
75
(19):
1670-7
Rost
NS, Fitzpatrick
K, Biffi
A, Kanakis
A, Devan
W, Anderson
CD, Cortellini
L, Furie
KL, Rosand
J
White matter hyperintensity burden and susceptibility to cerebral ischemia.
Stroke.
2010
Dec
;
41
(12):
2807-11
Anderson
CD, Biffi
A, Rahman
R, Ross
OA, Jagiella
JM, Kissela
B, Cole
JW, Cortellini
L, Rost
NS, Cheng
YC, Greenberg
SM, de Bakker
PI, Brown
RD, Brott
TG, Mitchell
BD, Broderick
JP, Worrall
BB, Furie
KL, Kittner
SJ, Woo
D, Slowik
A, Meschia
JF, Saxena
R, Rosand
J,
Common mitochondrial sequence variants in ischemic stroke.
Ann Neurol.
2011
Mar
;
69
(3):
471-80
Thompson
BB, Béjot
Y, Caso
V, Castillo
J, Christensen
H, Flaherty
ML, Foerch
C, Ghandehari
K, Giroud
M, Greenberg
SM, Hallevi
H, Hemphill
JC, Heuschmann
P, Juvela
S, Kimura
K, Myint
PK, Nagakane
Y, Naritomi
H, Passero
S, Rodríguez-Yáñez
MR, Roquer
J, Rosand
J, Rost
NS, Saloheimo
P, Salomaa
V, Sivenius
J, Sorimachi
T, Togha
M, Toyoda
K, Turaj
W, Vemmos
KN, Wolfe
CD, Woo
D, Smith
EE
Prior antiplatelet therapy and outcome following intracerebral hemorrhage: a systematic review.
Neurology.
2010
Oct
12;
75
(15):
1333-42
Biffi
A, Anderson
CD, Nalls
MA, Rahman
R, Sonni
A, Cortellini
L, Rost
NS, Matarin
M, Hernandez
DG, Plourde
A, de Bakker
PI, Ross
OA, Greenberg
SM, Furie
KL, Meschia
JF, Singleton
AB, Saxena
R, Rosand
J
Principal-component analysis for assessment of population stratification in mitochondrial medical genetics.
Am J Hum Genet.
2010
Jun
11;
86
(6):
904-17
Edlow
BL, Wainger
BJ, Frosch
MP, Copen
WA, Rathmell
JP, Rost
NS
Posterior circulation stroke after C1-C2 intraarticular facet steroid injection: evidence for diffuse microvascular injury.
Anesthesiology.
2010
Jun
;
112
(6):
1532-5
Rost
NS, Rahman
R, Sonni
S, Kanakis
A, Butler
C, Massasa
E, Cloonan
L, Gilson
A, Delgado
P, Chang
Y, Biffi
A, Jimenez-Conde
J, Besanger
A, Silva
G, Smith
EE, Rosand
J, Furie
KL
Determinants of white matter hyperintensity volume in patients with acute ischemic stroke.
J Stroke Cerebrovasc Dis.
2010
May
;
19
(3):
230-5
International Stroke Genetics Consortium
, Wellcome Trust Case-Control Consortium 2
Failure to validate association between 12p13 variants and ischemic stroke.
N Engl J Med.
2010
Apr
22;
362
(16):
1547-50
Anderson
CD, Biffi
A, Rost
NS, Cortellini
L, Furie
KL, Rosand
J
Chromosome 9p21 in ischemic stroke: population structure and meta-analysis.
Stroke.
2010
Jun
;
41
(6):
1123-31
Jimenez-Conde
J, Biffi
A, Rahman
R, Kanakis
A, Butler
C, Sonni
S, Massasa
E, Cloonan
L, Gilson
A, Capozzo
K, Cortellini
L, Ois
A, Cuadrado-Godia
E, Rodriguez-Campello
A, Furie
KL, Roquer
J, Rosand
J, Rost
NS
Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke.
Stroke.
2010
Mar
;
41
(3):
437-42
Rost
NS, Masrur
S, Pervez
MA, Viswanathan
A, Schwamm
LH
Unsuspected coagulopathy rarely prevents IV thrombolysis in acute ischemic stroke.
Neurology.
2009
Dec
8;
73
(23):
1957-62
Pervez
MA, Silva
G, Masrur
S, Betensky
R, Furie
KL, Renzo
H, Lima
F, Rosenthal
E, Rost
NS, Viswanathan
A, Schwamm
LH
Remote Supervision of IV-tPA for Acute Ischemic Stroke by Telemedicine or Telephone Prior to Transfer to a Regional Stroke Center is Feasible and Safe.
Stroke 2009;in press.
;
():
Morrow
DA, Scirica
BM, Fox
KA, Berman
G, Strony
J, Veltri
E, Bonaca
MP, Fish
P, McCabe
CH, Braunwald
E, TRA 2(o)P-TIMI 50 Investigators
Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial.
Am Heart J.
2009
Sep
;
158
(3):
335-341.e3
Kimberly
WT, Gilson
A, Rost
NS, Rosand
J, Viswanathan
A, Smith
EE, Greenberg
SM
Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy.
Neurology.
2009
Apr
7;
72
(14):
1230-5
Arsava
EM, Rahman
R, Rosand
J, Lu
J, Smith
EE, Rost
NS, Singhal
AB, Lev
MH, Furie
KL, Koroshetz
WJ, Sorensen
AG, Ay
H
Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke.
Neurology.
2009
Apr
21;
72
(16):
1403-10
Kumar
MA, Rost
NS, Snider
RW, Chanderraj
R, Greenberg
SM, Smith
EE, Rosand
J
Anemia and hematoma volume in acute intracerebral hemorrhage.
Crit Care Med.
2009
Apr
;
37
(4):
1442-7
Goldstein
JN, Fazen
LE, Wendell
L, Chang
Y, Rost
NS, Snider
R, Schwab
K, Chanderraj
R, Kabrhel
C, Kinnecom
C, Fitzmaurice
E, Smith
EE, Greenberg
SM, Rosand
J
Risk of thromboembolism following acute intracerebral hemorrhage.
Neurocrit Care.
2009
;
10
(1):
28-34
Rost
NS, Smith
EE, Chang
Y, Snider
RW, Chanderraj
R, Schwab
K, FitzMaurice
E, Wendell
L, Goldstein
JN, Greenberg
SM, Rosand
J
Prediction of functional outcome in patients with primary intracerebral hemorrhage: the FUNC score.
Stroke.
2008
Aug
;
39
(8):
2304-9
Rost
NS, Greenberg
SM, Rosand
J
The genetic architecture of intracerebral hemorrhage.
Stroke.
2008
Jul
;
39
(7):
2166-73
FitzMaurice
E, Wendell
L, Snider
R, Schwab
K, Chanderraj
R, Kinnecom
C, Nandigam
K, Rost
NS, Viswanathan
A, Rosand
J, Greenberg
SM, Smith
EE
Effect of statins on intracerebral hemorrhage outcome and recurrence.
Stroke.
2008
Jul
;
39
(7):
2151-4
Rosand
J, Bayley
N, Rost
N, de Bakker
PI
Many hypotheses but no replication for the association between PDE4D and stroke.
Nat Genet.
2006
Oct
;
38
(10):
1091-2; author reply 1092-3
Rost
NS, Wolf
PA, Kase
CS, Kelly-Hayes
M, Silbershatz
H, Massaro
JM, D'Agostino
RB, Franzblau
C, Wilson
PW
Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study.
Stroke.
2001
Nov
;
32
(11):
2575-9
Rost
NS, Murphy
K, Hafer
L, Pavao
M, Traish
AM
Immunochemical analyses of estrogen receptors in human breast tumors by a novel monoclonal estrogen receptor antibody (EVG F9).
Steroids.
2000
Aug
;
65
(8):
429-36