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Leigh R. Hochberg, M.D., Ph.D.

Leigh R. Hochberg, M.D., Ph.D.

Titles and Contact Information

Associate Neurologist, Massachusetts General Hospital

Associate Neurologist, Brigham and Women's Hospital

Consulting Staff in Neurology, Spaulding Rehabilitation Hospital

Investigator, Rehabilitation R&D, Dept. Veterans Affairs

Visiting Associate Professor of Neurology, Harvard Medical School

Associate Professor of Engineering, Brown University

Appointments: (617) 726-4218

Affiliations and Profiles

Clinical Interests

  • Stroke
  • Neurocritical Care

Current Projects

BrainGate Clinical Trials

Clinical Background

1999 M.D. Degree Emory University School of Medicine
1999 Ph.D. Degree Emory University Neuroscience
2000 Internship Grady Memorial Hospital and Emory Affiliated Hospitals
Internal Medicine
2000 - 2003 Residency Massachusetts General Hospital / Brigham and Women's Hospital
2003 - 2004 Fellowship Massachusetts General Hospital / Brigham and Women's Hospital
Stroke and NeuroCritical Care
2005 Board Certification Neurology
2008 Board Certification Vascular Neurology
2011 Board Certification Neurocritical Care


Chadwick EK, Blana D, Simeral JD, Lambrecht J, Kim SP, Cornwell AS, Taylor DM, Hochberg LR, Donoghue JP, Kirsch RF
Continuous neuronal ensemble control of simulated arm reaching by a human with tetraplegia.
J Neural Eng. 2011 Jun ; 8 (3): 034003

Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS, Brown EN, Halgren E, Cash SS
Single-neuron dynamics in human focal epilepsy.
Nat Neurosci. 2011 May ; 14 (5): 635-41

Simeral JD, Kim SP, Black MJ, Donoghue JP, Hochberg LR
Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array.
J Neural Eng. 2011 Apr ; 8 (2): 025027

Kim SP, Simeral JD, Hochberg LR, Donoghue JP, Friehs GM, Black MJ
Point-and-click cursor control with an intracortical neural interface system by humans with tetraplegia.
IEEE Trans Neural Syst Rehabil Eng. 2011 Apr ; 19 (2): 193-203

Ajiboye AB, Hochberg LR, Donoghue JP, Kirsch RF
Application of system identification methods for decoding imagined single-joint movements in an individual with high tetraplegia.
Conf Proc IEEE Eng Med Biol Soc. 2010 ; 2010 (): 2678-81

Malik WQ, Truccolo W, Brown EN, Hochberg LR
Efficient decoding with steady-state Kalman filter in neural interface systems.
IEEE Trans Neural Syst Rehabil Eng. 2011 Feb ; 19 (1): 25-34

Keller CJ, Truccolo W, Gale JT, Eskandar E, Thesen T, Carlson C, Devinsky O, Kuzniecky R, Doyle WK, Madsen JR, Schomer DL, Mehta AD, Brown EN, Hochberg LR, Ulbert I, Halgren E, Cash SS
Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex.
Brain. 2010 Jun ; 133 (Pt 6): 1668-81

Nurmikko AV, Donoghue JP, Hochberg LR, Patterson WR, Song YK, Bull CW, Borton DA, Laiwalla F, Park S, Ming Y, Aceros J
Listening to Brain Microcircuits for Interfacing With External World-Progress in Wireless Implantable Microelectronic Neuroengineering Devices: Experimental systems are described for electrical recording in the brain using multiple microelectrodes and short range implantable or wearable broadcasting units.
Proc IEEE Inst Electr Electron Eng. 2010 ; 98 (3): 375-388

Truccolo W, Hochberg LR, Donoghue JP
Collective dynamics in human and monkey sensorimotor cortex: predicting single neuron spikes.
Nat Neurosci. 2010 Jan ; 13 (1): 105-11

Kim SP, Simeral JD, Hochberg LR, Donoghue JP, Black MJ
Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia.
J Neural Eng. 2008 Dec ; 5 (4): 455-76

Hochberg LR
Turning thought into action.
N Engl J Med. 2008 Sep 11; 359 (11): 1175-7

Truccolo W, Friehs GM, Donoghue JP, Hochberg LR
Primary motor cortex tuning to intended movement kinematics in humans with tetraplegia.
J Neurosci. 2008 Jan 30; 28 (5): 1163-78

Kim SP, Simeral JD, Hochberg LR, Donoghue JP, Friehs GM, Black MJ
Multi-state decoding of point-and-click control signals from motor cortical activity in a human with tetraplegia.
3rd International IEEE-EMBS Conference 2007 May:486-489. ; ():

Donoghue JP, Hochberg LR, Nurmikko AV, Black MJ, Simeral JD, Friehs G
Neuromotor prosthesis development.
Med Health R I. 2007 Jan ; 90 (1): 12-5

Hochberg LR, Taylor DM
Intuitive prosthetic limb control.
Lancet. 2007 Feb 3; 369 (9559): 345-6

Donoghue JP, Nurmikko A, Black M, Hochberg LR
Assistive technology and robotic control using motor cortex ensemble-based neural interface systems in humans with tetraplegia.
J Physiol. 2007 Mar 15; 579 (Pt 3): 603-11

Hochberg LR, Donoghue JP
Sensors for brain-computer interfaces.
IEEE Eng Med Biol Mag. ; 25 (5): 32-8

Aaron RK, Herr HM, Ciombor DM, Hochberg LR, Donoghue JP, Briant CL, Morgan JR, Ehrlich MG
Horizons in prosthesis development for the restoration of limb function.
J Am Acad Orthop Surg. 2006 Oct ; 14 (10 Suppl): S198-204

Hochberg LR, Serruya MD, Friehs GM, Mukand JA, Saleh M, Caplan AH, Branner A, Chen D, Penn RD, Donoghue JP
Neuronal ensemble control of prosthetic devices by a human with tetraplegia.
Nature. 2006 Jul 13; 442 (7099): 164-71

K├╝bler A, Mushahwar VK, Hochberg LR, Donoghue JP
BCI Meeting 2005--workshop on clinical issues and applications.
IEEE Trans Neural Syst Rehabil Eng. 2006 Jun ; 14 (2): 131-4

Hochberg LR, Sims JR, Davis BT
West Nile encephalitis in Massachusetts.
N Engl J Med. 2002 Mar 28; 346 (13): 1030-1

Burrow M, Dugger J, Humphrey DR, Reed DJ, Hochberg LR
Cortical control of a robot using a time-delay neural network.
International Conference on Rehabilitation Robotics, 1997. ; ():

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In the News

The MGH Neurology Department placed 4th in US News Neurology / NeuroSurgery rankings for 2013-14.

Educational Video

Still from the Stroke Evaluation simulation

This video simulation of an Emergency stroke evaluation illustrates the care of patients with acute stroke by the MGH Acute Stroke team.