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David N. Caplan, M.D., PH.D.

David Norman Caplan, MD, PHD

Title and Contact Information

Professor, Massachusetts General Hospital Neurology

Appointments: 617-726-3274
Fax Number: 617-724-7836

Clinical Interests

  • Behavioral Neurology
  • Alzheimer's Disease
  • Language Disorders

Clinical Background

MD Degree McGill University
Doctorate Massachusetts Institute of Technology
Board Certification Neurology (Lifetime)




Caplan D
Aphasic deficits in syntactic processing.
Cortex. 2006 Aug ; 42 (6): 797-804

Caplan D, Waters G, Dede G, Michaud J, Reddy A
A study of syntactic processing in aphasia I: behavioral (psycholinguistic) aspects.
Brain Lang. 2007 May ; 101 (2): 103-50

Caplan D, Waters G, Kennedy D, Alpert N, Makris N, Dede G, Michaud J, Reddy A
A study of syntactic processing in aphasia II: neurological aspects.
Brain Lang. 2007 May ; 101 (2): 151-77

Chen E, West WC, Waters G, Caplan D
Determinants of bold signal correlates of processing object-extracted relative clauses.
Cortex. 2006 May ; 42 (4): 591-604

Caplan D
Why is Broca's area involved in syntax?
Cortex. 2006 May ; 42 (4): 469-71

Kuperberg GR, Lakshmanan BM, Caplan DN, Holcomb PJ
Making sense of discourse: an fMRI study of causal inferencing across sentences.
Neuroimage. 2006 Oct 15; 33 (1): 343-61

Guerry M, Gimenes M, Caplan D, Rigalleau F
How long does it take to find a cause? An online investigation of implicit causality in sentence production.
Q J Exp Psychol (Colchester). 2006 Sep ; 59 (9): 1535-55

Caplan D, Chen E
Using fMRI to discover cognitive operations.
Cortex. 2006 Apr ; 42 (3): 393-5; discussion 422-7

Kuperberg GR, Kreher DA, Sitnikova T, Caplan DN, Holcomb PJ
The role of animacy and thematic relationships in processing active English sentences: evidence from event-related potentials.
Brain Lang. 2007 Mar ; 100 (3): 223-37

Schmahmann JD, Caplan D
Cognition, emotion and the cerebellum.
Brain. 2006 Feb ; 129 (Pt 2): 290-2

Caplan D, DeDe G, Brownell H
Effects of syntactic features on sentence-picture matching in Broca's aphasics: a reply to Drai and Grodzinksy (2005).
Brain Lang. 2006 Feb ; 96 (2): 129-34; discussion 157-70

Waters G, Caplan D
The relationship between age, processing speed, working memory capacity, and language comprehension.
Memory. ; 13 (3-4): 403-13

DeDe G, Caplan D, Kemtes K, Waters G
The relationship between age, verbal working memory, and language comprehension.
Psychol Aging. 2004 Dec ; 19 (4): 601-16

Doherty CP, West WC, Dilley LC, Shattuck-Hufnagel S, Caplan D
Question/statement judgments: an fMRI study of intonation processing.
Hum Brain Mapp. 2004 Oct ; 23 (2): 85-98

Rigalleau F, Caplan D, Baudiffier V
New arguments in favour of an automatic gender pronominal process.
Q J Exp Psychol A. 2004 Jul ; 57 (5): 893-933

Rigalleau F, Baudiffier V, Caplan D
Comprehension of sentences with stylistic inversion by French aphasic patients.
Brain Lang. 2004 Apr ; 89 (1): 142-56

Caplan D, Moo L
Cognitive conjunction and cognitive functions.
Neuroimage. 2004 Feb ; 21 (2): 751-6

Waters GS, Caplan D
The reliability and stability of verbal working memory measures.
Behav Res Methods Instrum Comput. 2003 Nov ; 35 (4): 550-64

Waters GS, Caplan D
Verbal working memory and on-line syntactic processing: evidence from self-paced listening.
Q J Exp Psychol A. 2004 Jan ; 57 (1): 129-63

Waters G, Caplan D, Alpert N, Stanczak L
Individual differences in rCBF correlates of syntactic processing in sentence comprehension: effects of working memory and speed of processing.
Neuroimage. 2003 May ; 19 (1): 101-12

Caplan D, Waters G, Alpert N
Effects of age and speed of processing on rCBF correlates of syntactic processing in sentence comprehension.
Hum Brain Mapp. 2003 Jun ; 19 (2): 112-31

Kuperberg GR, Sitnikova T, Caplan D, Holcomb PJ
Electrophysiological distinctions in processing conceptual relationships within simple sentences.
Brain Res Cogn Brain Res. 2003 Jun ; 17 (1): 117-29

Waters G, Caplan D, Yampolsky S
On-line syntactic processing under concurrent memory load.
Psychon Bull Rev. 2003 Mar ; 10 (1): 88-95

Kuperberg GR, Holcomb PJ, Sitnikova T, Greve D, Dale AM, Caplan D
Distinct patterns of neural modulation during the processing of conceptual and syntactic anomalies.
J Cogn Neurosci. 2003 Feb 15; 15 (2): 272-93

Hoen M, Golembiowski M, Guyot E, Deprez V, Caplan D, Dominey PF
Training with cognitive sequences improves syntactic comprehension in agrammatic aphasics.
Neuroreport. 2003 Mar 3; 14 (3): 495-9

Caplan D, Waters G
On-line syntactic processing in aphasia: studies with auditory moving window presentation.
Brain Lang. 2003 Feb ; 84 (2): 222-49

Chee MW, Caplan D
Face encoding and psychometric testing in healthy dextrals with right hemisphere language.
Neurology. 2002 Dec 24; 59 (12): 1928-34

Caviness VS, Makris N, Montinaro E, Sahin NT, Bates JF, Schwamm L, Caplan D, Kennedy DN
Anatomy of stroke, Part II: volumetric characteristics with implications for the local architecture of the cerebral perfusion system.
Stroke. 2002 Nov ; 33 (11): 2557-64

Caviness VS, Makris N, Montinaro E, Sahin NT, Bates JF, Schwamm L, Caplan D, Kennedy DN
Anatomy of stroke, Part I: an MRI-based topographic and volumetric System of analysis.
Stroke. 2002 Nov ; 33 (11): 2549-56

Waters G, Caplan D
Working memory and online syntactic processing in Alzheimer's disease: studies with auditory moving window presentation.
J Gerontol B Psychol Sci Soc Sci. 2002 Jul ; 57 (4): P298-311

Yampolsky S, Waters G, Caplan D, Matthies M, Chiu P
Effects of acoustic degradation on syntactic processing: implications for the nature of the resource system used in language processing.
Brain Cogn. ; 48 (2-3): 617-25

Chee MW, Hon NH, Caplan D, Lee HL, Goh J
Frequency of concrete words modulates prefrontal activation during semantic judgments.
Neuroimage. 2002 May ; 16 (1): 259-68

Caplan D, Vijayan S, Kuperberg G, West C, Waters G, Greve D, Dale AM
Vascular responses to syntactic processing: event-related fMRI study of relative clauses.
Hum Brain Mapp. 2002 Jan ; 15 (1): 26-38

Caplan D
Functional neuroimaging studies of syntactic processing.
J Psycholinguist Res. 2001 May ; 30 (3): 297-320

Waters GS, Caplan D
Age, working memory, and on-line syntactic processing in sentence comprehension.
Psychol Aging. 2001 Mar ; 16 (1): 128-44

Caplan D, Waters GS
Verbal working memory and sentence comprehension.
Behav Brain Sci. 1999 Feb ; 22 (1): 77-94; discussion 95-126

Caplan D
The measurement of chance performance in aphasia, with specific reference to the comprehension of semantically reversible passive sentences: a note on issues raised by Caramazza, Capitani, Rey, and Berndt (2001) and Drai, Grodzinsky, and Zurif (2001).
Brain Lang. 2001 Feb ; 76 (2): 193-201

Titone D, Wingfield A, Caplan D, Waters G, Prentice K
Memory and encoding of spoken discourse following right hemisphere damage: evidence from the Auditory Moving Window (AMW) technique.
Brain Lang. 2001 Apr ; 77 (1): 10-24

Caplan D
Language-related cortex in deaf individuals: functional specialization for language or perceptual plasticity?
Proc Natl Acad Sci U S A. 2000 Dec 5; 97 (25): 13476-7

Rochon E, Waters GS, Caplan D
The relationship between measures of working memory and sentence comprehension in patients with Alzheimer's disease.
J Speech Lang Hear Res. 2000 Apr ; 43 (2): 395-413

Rigalleau F, Caplan D
Effects of gender marking in pronominal coindexation.
Q J Exp Psychol A. 2000 Feb ; 53 (1): 23-52

Caplan D, Alpert N, Waters G, Olivieri A
Activation of Broca's area by syntactic processing under conditions of concurrent articulation.
Hum Brain Mapp. 2000 Feb ; 9 (2): 65-71

Caplan D
Activating brain systems for syntax and semantics.
Neuron. 1999 Oct ; 24 (2): 292-3

Chee MW, Caplan D, Soon CS, Sriram N, Tan EW, Thiel T, Weekes B
Processing of visually presented sentences in Mandarin and English studied with fMRI.
Neuron. 1999 May ; 23 (1): 127-37

Caplan D, Alpert N, Waters G
PET studies of syntactic processing with auditory sentence presentation.
Neuroimage. 1999 Mar ; 9 (3): 343-51

Caplan D, Alpert N, Waters G
Effects of syntactic structure and propositional number on patterns of regional cerebral blood flow.
J Cogn Neurosci. 1998 Jul ; 10 (4): 541-52

Caplan D, Hanna JE
Sentence production by aphasic patients in a constrained task.
Brain Lang. 1998 Jun 15; 63 (2): 184-218

Waters GS, Rochon E, Caplan D
Task demands and sentence comprehension in patients with dementia of the Alzheimer's type.
Brain Lang. 1998 May ; 62 (3): 361-97

Waters GS, Caplan D
Working memory and on-line sentence comprehension in patients with Alzheimer's disease.
J Psycholinguist Res. 1997 Jul ; 26 (4): 377-400

Caplan D, Waters GS, Hildebrandt N
Determinants of sentence comprehension in aphasic patients in sentence-picture matching tasks.
J Speech Lang Hear Res. 1997 Jun ; 40 (3): 542-55

Leonard CL, Waters GS, Caplan D
The use of contextual information related to general world knowledge by right brain-damaged individuals in pronoun resolution.
Brain Lang. 1997 May ; 57 (3): 343-59

Leonard CL, Waters GS, Caplan D
The use of contextual information by right brain-damaged individuals in the resolution of ambiguous pronouns.
Brain Lang. 1997 May ; 57 (3): 309-42

Waters GS, Caplan D
The capacity theory of sentence comprehension: critique of Just and Carpenter (1992)
Psychol Rev. 1996 Oct ; 103 (4): 761-72

Caplan D, Hildebrandt N, Makris N
Location of lesions in stroke patients with deficits in syntactic processing in sentence comprehension.
Brain. 1996 Jun ; 119 ( Pt 3) (): 933-49

Waters GS, Caplan D
Processing resource capacity and the comprehension of garden path sentences.
Mem Cognit. 1996 May ; 24 (3): 342-55

Stromswold K, Caplan D, Alpert N, Rauch S
Localization of syntactic comprehension by positron emission tomography.
Brain Lang. 1996 Mar ; 52 (3): 452-73

Waters GS, Caplan D
The measurement of verbal working memory capacity and its relation to reading comprehension.
Q J Exp Psychol A. 1996 Feb ; 49 (1): 51-75

Gow DW, Caplan D
An examination of impaired acoustic-phonetic processing in aphasia.
Brain Lang. 1996 Feb ; 52 (2): 386-407

Caplan D
Issues arising in contemporary studies of disorders of syntactic processing in sentence comprehension in agrammatic patients.
Brain Lang. 1995 Sep ; 50 (3): 325-38

Hildebrandt N, Caplan D, Sokol S, Torreano L
Lexical factors in the word-superiority effect.
Mem Cognit. 1995 Jan ; 23 (1): 23-33

Caplan D, Waters GS
Articulatory length and phonological similarity in span tasks: a reply to Baddeley and Andrade.
Q J Exp Psychol A. 1994 Nov ; 47 (4): 1055-62

Rochon E, Waters GS, Caplan D
Sentence comprehension in patients with Alzheimer's disease.
Brain Lang. 1994 Feb ; 46 (2): 329-49

Caplan D, Utman JA
Selective acoustic phonetic impairment and lexical access in an aphasic patient.
J Acoust Soc Am. 1994 Jan ; 95 (1): 512-7

Caplan D, Rochon E, Waters GS
Articulatory and phonological determinants of word length effects in span tasks.
Q J Exp Psychol A. 1992 Aug ; 45 (2): 177-92

Damecour CL, Caplan D
The relationship of depression to symptomatology and lesion site in aphasic patients.
Cortex. 1991 Sep ; 27 (3): 385-401

Caplan D
Agrammatism is a theoretically coherent aphasic category.
Brain Lang. 1991 Feb ; 40 (2): 274-81

Caplan D, Evans KL
The effects of syntactic structure on discourse comprehension in patients with parsing impairments.
Brain Lang. 1990 Aug ; 39 (2): 206-34

Butler-Hinz S, Caplan D, Waters G
Characteristics of syntactic comprehension deficits following closed head injury versus left cerebrovascular accident.
J Speech Hear Res. 1990 Jun ; 33 (2): 269-80

Nespoulous JL, Dordain M, Perron C, Ska B, Bub D, Caplan D, Mehler J, Lecours AR
Agrammatism in sentence production without comprehension deficits: reduced availability of syntactic structures and/or of grammatical morphemes? A case study.
Brain Lang. 1988 Mar ; 33 (2): 273-95

Caplan D
Agrammatism and the coindexation of traces: comments on Grodzinsky's reply.
Brain Lang. 1987 Jan ; 30 (1): 191-3

Caplan D
Discrimination of normal and aphasic subjects on a test of syntactic comprehension.
Neuropsychologia. 1987 ; 25 (1B): 173-84

Caplan D
In defense of agrammatism.
Cognition. 1986 Dec ; 24 (3): 263-76

Caplan D, Hildebrandt N
Language deficits and the theory of syntax: a reply to Grodzinsky.
Brain Lang. 1986 Jan ; 27 (1): 168-77

Caplan D, Futter C
Assignment of thematic roles to nouns in sentence comprehension by an agrammatic patient.
Brain Lang. 1986 Jan ; 27 (1): 117-34

Caplan D, Baker C, Dehaut F
Syntactic determinants of sentence comprehension in aphasia.
Cognition. 1985 Nov ; 21 (2): 117-75

Lecours AR, Caplan D
Augusta Dejerine-Klumpke or "The Lesson in Anatomy".
Brain Cogn. 1984 Apr ; 3 (2): 166-97

Nespoulous JL, Joanette Y, BĂ©land R, Caplan D, Lecours AR
Phonologic disturbances in aphasia: is there a "markedness effect" in aphasic phonetic errors?
Adv Neurol. 1984 ; 42 (): 203-14

Caplan D
A note on the "word-order problem" in agrammatism.
Brain Lang. 1983 Sep ; 20 (1): 155-65

Caplan D
On the cerebral localization of linguistic functions: logical and empirical issues surrounding deficit analysis and functional localization.
Brain Lang. 1981 Sep ; 14 (1): 120-37

Caplan D
Prospects for neurolinguistic theory.
Cognition. ; 10 (1-3): 59-64

Caplan D, Matthei E, Gigley H
Comprehension of gerundive constructions by Broca's aphasics.
Brain Lang. 1981 May ; 13 (1): 145-69

Marshall JC, Caplan D, Holmes JM
The measure of laterality.
Neuropsychologia. 1975 Sep ; 13 (3): 315-21

Caplan D, Holmes JM, Marshall JC
Word classes and hemispheric specialization.
Neuropsychologia. 1974 Jul ; 12 (3): 331-7

Caplan D, Kellar L, Locke S
Inflection of neologisms in aphasia.
Brain. 1972 ; 95 (1): 169-72

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