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Cenk Ayata, M.D.

Cenk Ayata M.D.

Title and Contact Information

Assistant Professor, Massachusetts General Hospital

Appointments: 617.726.8459 option 3
Fax Number: 617-726-2547

Clinical Interests

  • Vascular Neurology
  • Stroke
  • Neurologic Intensive Care

Clinical Background

1994 M.D. Degree Hacettepe University
Faculty of Medicine
2001 - 2003 Fellowship Massachusetts General Hospital
N/A Board Ceritifcation Neurology


Lee SR, Lok J, Rosell A, Kim HY, Murata Y, Atochin D, Huang PL, Wang X, Ayata C, Moskowitz MA, Lo EH
Reduction of hippocampal cell death and proteolytic responses in tissue plasminogen activator knockout mice after transient global cerebral ischemia.
Neuroscience. 2007 Oct 11; ():

Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG
A Computerized Algorithm for Etiologic Classification of Ischemic Stroke. The Causative Classification of Stroke System.
Stroke. 2007 Sep 27; ():

Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C
Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy.
Brain. 2007 Sep ; 130 (Pt 9): 2310-9

Atochin DN, Wang A, Liu VW, Critchlow JD, Dantas AP, Looft-Wilson R, Murata T, Salomone S, Shin HK, Ayata C, Moskowitz MA, Michel T, Sessa WC, Huang PL
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo.
J Clin Invest. 2007 Jul ; 117 (7): 1961-7

Shin HK, Dunn AK, Jones PB, Boas DA, Lo EH, Moskowitz MA, Ayata C
Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia.
Brain. 2007 Jun ; 130 (Pt 6): 1631-42

Shin HK, Salomone S, Potts EM, Lee SW, Millican E, Noma K, Huang PL, Boas DA, Liao JK, Moskowitz MA, Ayata C
Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.
J Cereb Blood Flow Metab. 2007 May ; 27 (5): 998-1009

Ay H, Koroshetz WJ, Benner T, Vangel MG, Melinosky C, Arsava EM, Ayata C, Zhu M, Schwamm LH, Sorensen AG
Neuroanatomic correlates of stroke-related myocardial injury.
Neurology. 2006 May 9; 66 (9): 1325-9

Ayata C, Jin H, Kudo C, Dalkara T, Moskowitz MA
Suppression of cortical spreading depression in migraine prophylaxis.
Ann Neurol. 2006 Apr ; 59 (4): 652-61

Shin HK, Dunn AK, Jones PB, Boas DA, Moskowitz MA, Ayata C
Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.
J Cereb Blood Flow Metab. 2006 Aug ; 26 (8): 1018-30

Ayata C, Moskowitz MA
Cortical spreading depression confounds concentration-dependent pial arteriolar dilation during N-methyl-D-aspartate superfusion.
Am J Physiol Heart Circ Physiol. 2006 May ; 290 (5): H1837-41

Badjatia N, O'Donnell J, Baker JR, Huang D, Ayata C, Greer DM, Carter BS, Ogilvy CS, McDonald CT
Achieving normothermia in patients with febrile subarachnoid hemorrhage: feasibility and safety of a novel intravascular cooling catheter.
Neurocrit Care. 2004 ; 1 (2): 145-56

Ayata C, Shin HK, Salomone S, Ozdemir-Gursoy Y, Boas DA, Dunn AK, Moskowitz MA
Pronounced hypoperfusion during spreading depression in mouse cortex.
J Cereb Blood Flow Metab. 2004 Oct ; 24 (10): 1172-82

Atochin DN, Murciano JC, G├╝rsoy-Ozdemir Y, Krasik T, Noda F, Ayata C, Dunn AK, Moskowitz MA, Huang PL, Muzykantov VR
Mouse model of microembolic stroke and reperfusion.
Stroke. 2004 Sep ; 35 (9): 2177-82

Ayata C, Dunn AK, Gursoy-OZdemir Y, Huang Z, Boas DA, Moskowitz MA
Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex.
J Cereb Blood Flow Metab. 2004 Jul ; 24 (7): 744-55

Ropper AH, Ayata C, Adelman L
Vasculitis of the spinal cord.
Arch Neurol. 2003 Dec ; 60 (12): 1791-4

Ayata C, Ropper AH
Intensive care management of specific stroke treatment.
Adv Neurol. 2003 ; 92 (): 361-77

Qureshi AI, Suarez JI, Yahia AM, Mohammad Y, Uzun G, Suri MF, Zaidat OO, Ayata C, Ali Z, Wityk RJ
Timing of neurologic deterioration in massive middle cerebral artery infarction: a multicenter review.
Crit Care Med. 2003 Jan ; 31 (1): 272-7

Ayata C, Ropper AH
Ischaemic brain oedema.
J Clin Neurosci. 2002 Mar ; 9 (2): 113-24

Ayata C, Shimizu-Sasamata M, Lo EH, Noebels JL, Moskowitz MA
Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels.
Neuroscience. 2000 ; 95 (3): 639-45

Mandeville JB, Marota JJ, Ayata C, Moskowitz MA, Weisskoff RM, Rosen BR
MRI measurement of the temporal evolution of relative CMRO(2) during rat forepaw stimulation.
Magn Reson Med. 1999 Nov ; 42 (5): 944-51

Mandeville JB, Marota JJ, Ayata C, Zaharchuk G, Moskowitz MA, Rosen BR, Weisskoff RM
Evidence of a cerebrovascular postarteriole windkessel with delayed compliance.
J Cereb Blood Flow Metab. 1999 Jun ; 19 (6): 679-89

Marota JJ, Ayata C, Moskowitz MA, Weisskoff RM, Rosen BR, Mandeville JB
Investigation of the early response to rat forepaw stimulation.
Magn Reson Med. 1999 Feb ; 41 (2): 247-52

Browne SE, Ayata C, Huang PL, Moskowitz MA, Beal MF
The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice.
J Cereb Blood Flow Metab. 1999 Feb ; 19 (2): 144-8

Meng W, Ayata C, Waeber C, Huang PL, Moskowitz MA
Neuronal NOS-cGMP-dependent ACh-induced relaxation in pial arterioles of endothelial NOS knockout mice.
Am J Physiol. 1998 Feb ; 274 (2 Pt 2): H411-5

Ayata C, Ayata G, Hara H, Matthews RT, Beal MF, Ferrante RJ, Endres M, Kim A, Christie RH, Waeber C, Huang PL, Hyman BT, Moskowitz MA
Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.
J Neurosci. 1997 Sep 15; 17 (18): 6908-17

Hara H, Ayata C, Huang PL, Waeber C, Ayata G, Fujii M, Moskowitz MA
[3H]L-NG-nitroarginine binding after transient focal ischemia and NMDA-induced excitotoxicity in type I and type III nitric oxide synthase null mice.
J Cereb Blood Flow Metab. 1997 May ; 17 (5): 515-26

Demirci M, Ayata C, Dalkara T, Erdemli G, Onur R
Monitoring cellular edema at single-neuron level by electrical resistance measurements.
J Neurosci Methods. 1997 Apr 4; 72 (2): 175-81

Okamoto H, Meng W, Ma J, Ayata C, Roman RJ, Bosnjak ZJ, Kampine JP, Huang PL, Moskowitz MA, Hudetz AG
Isoflurane-induced cerebral hyperemia in neuronal nitric oxide synthase gene deficient mice.
Anesthesiology. 1997 Apr ; 86 (4): 875-84

Hara H, Friedlander RM, Gagliardini V, Ayata C, Fink K, Huang Z, Shimizu-Sasamata M, Yuan J, Moskowitz MA
Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.
Proc Natl Acad Sci U S A. 1997 Mar 4; 94 (5): 2007-12

Ma J, Meng W, Ayata C, Huang PL, Fishman MC, Moskowitz MA
L-NNA-sensitive regional cerebral blood flow augmentation during hypercapnia in type III NOS mutant mice.
Am J Physiol. 1996 Oct ; 271 (4 Pt 2): H1717-9

Meng W, Ma J, Ayata C, Hara H, Huang PL, Fishman MC, Moskowitz MA
ACh dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms.
Am J Physiol. 1996 Sep ; 271 (3 Pt 2): H1145-50

Huang Z, Huang PL, Ma J, Meng W, Ayata C, Fishman MC, Moskowitz MA
Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine.
J Cereb Blood Flow Metab. 1996 Sep ; 16 (5): 981-7

Ayata C, Ma J, Meng W, Huang P, Moskowitz MA
L-NA-sensitive rCBF augmentation during vibrissal stimulation in type III nitric oxide synthase mutant mice.
J Cereb Blood Flow Metab. 1996 Jul ; 16 (4): 539-41

Ma J, Ayata C, Huang PL, Fishman MC, Moskowitz MA
Regional cerebral blood flow response to vibrissal stimulation in mice lacking type I NOS gene expression.
Am J Physiol. 1996 Mar ; 270 (3 Pt 2): H1085-90

Dalkara T, Ayata C, Demirci M, Erdemli G, Onur R
Effects of cerebral ischemia on N-methyl-D-aspartate and dihydropyridine-sensitive calcium currents. An electrophysiological study in the rat hippocampus in situ.
Stroke. 1996 Jan ; 27 (1): 127-33

Lee WS, Limmroth V, Ayata C, Cutrer FM, Waeber C, Yu X, Moskowitz MA
Peripheral GABAA receptor-mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation.
Br J Pharmacol. 1995 Sep ; 116 (1): 1661-7

Onur R, Bozdagi O, Ayata C
Effects of aconitine on neurotransmitter release in the rat neuromuscular junction.
Neuropharmacology. 1995 Sep ; 34 (9): 1139-45

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