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Aneesh B. Singhal, M.D.

Aneesh Bhim Singhal, MD

Titles and Contact Information

Associate Professor of Neurology, Harvard Medical School

Neurologist, Massachusetts General Hospital

Director, Quality and Safety, Massachusetts General Hospital, Neurology Department

Director, Stroke and Neuro-ICU Observership Program, Massachusetts General Hospital

Director, Neurology Consultations, Spaulding Rehabilitation Hospital

Appointments: 617.726.8459
Fax Number: 617.726.5043

Affiliations and Profiles

Clinical Interests

  • Acute stroke treatment
  • Stroke neuroimaging
  • Cerebral vasoconstriction syndromes
  • Stroke in young adults

Clinical Background

1995 M.D. Degree Bombay University, India
1995 Board Certification Internal Medicine, Bombay University, India
1999 Residency Massachusetts General Hospital
2000 Board Certification Neurology
2000 Board Certification Neurosonology
2001 Fellowship Massachusetts General Hospital
Cerebrovascular Disease


Striano P, Morana G, Rossi A, Domoto-Reilly K, Singhal AB
Licorice-associated reversible cerebral vasoconstriction with PRES.
Neurology. 2011 Jul 5; 77 (1): 87-8

Singhal AB
Diagnostic challenges in RCVS, PACNS, and other cerebral arteriopathies.
Cephalalgia. 2011 Jul ; 31 (10): 1067-70

Hajj-Ali RA, Singhal AB, Benseler S, Molloy E, Calabrese LH
Primary angiitis of the CNS.
Lancet Neurol. 2011 Jun ; 10 (6): 561-72

Singhal AB, Hajj-Ali RA, Topcuoglu MA, Fok J, Bena J, Yang D, Calabrese LH
Reversible cerebral vasoconstriction syndromes: analysis of 139 cases.
Arch Neurol. 2011 Aug ; 68 (8): 1005-12

Fujiwara N, Mandeville ET, Geng X, Luo Y, Arai K, Wang X, Ji X, Singhal AB, Lo EH
Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage.
Stroke. 2011 May ; 42 (5): 1469-72

Gokcay F, Arsava EM, Baykaner T, Vangel M, Garg P, Wu O, Singhal AB, Furie KL, Sorensen AG, Ay H
Age-dependent susceptibility to infarct growth in women.
Stroke. 2011 Apr ; 42 (4): 947-51

Maas MB, Lev MH, Ay H, Singhal AB, Greer DM, Smith WS, Harris GJ, Halpern EF, Koroshetz WJ, Furie KL
The Prognosis for Aphasia in Stroke.
J Stroke Cerebrovasc Dis. 2010 Dec 23; ():

Chatterjee N, Domoto-Reilly K, Fecci PE, Schwamm LH, Singhal AB
Licorice-associated reversible cerebral vasoconstriction with PRES.
Neurology. 2010 Nov 23; 75 (21): 1939-41

Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H,
The Causative Classification of Stroke system: an international reliability and optimization study.
Neurology. 2010 Oct 5; 75 (14): 1277-84

Lima FO, Furie KL, Silva GS, Lev MH, Camargo EC, Singhal AB, Harris GJ, Halpern EF, Koroshetz WJ, Smith WS, Yoo AJ, Nogueira RG
The pattern of leptomeningeal collaterals on CT angiography is a strong predictor of long-term functional outcome in stroke patients with large vessel intracranial occlusion.
Stroke. 2010 Oct ; 41 (10): 2316-22

Soo Y, Singhal AB, Leung T, Yu S, Mak H, Hao Q, Leung H, Lam W, Wong LK
Reversible cerebral vasoconstriction syndrome with posterior leucoencephalopathy after oral contraceptive pills.
Cephalalgia. 2010 Jan ; 30 (1): 42-5

González RG, Hakimelahi R, Schaefer PW, Roccatagliata L, Sorensen AG, Singhal AB
Stability of large diffusion/perfusion mismatch in anterior circulation strokes for 4 or more hours.
BMC Neurol. 2010 ; 10 (): 13

Silva GS, Lima FO, Camargo EC, Smith WS, Singhal AB, Greer DM, Ay H, Lev MH, Harris GJ, Halpern EF, Sonni S, Koroshetz W, Furie KL
Wake-up stroke: clinical and neuroimaging characteristics.
Cerebrovasc Dis. 2010 ; 29 (4): 336-42

Lima FO, Lev MH, Levy RA, Silva GS, Ebril M, de Camargo EC, Pomerantz S, Singhal AB, Greer DM, Ay H, González RG, Koroshetz WJ, Smith WS, Furie KL
Functional contrast-enhanced CT for evaluation of acute ischemic stroke does not increase the risk of contrast-induced nephropathy.
AJNR Am J Neuroradiol. 2010 May ; 31 (5): 817-21

Jamshidi S, Kandiah PA, Singhal AB, Resnick JB, Furie KL, Borczuk P, Parry BA, Lev M, Koroshetz WJ, Chang Y, Nagurney JT
Clinical predictors of significant findings on head computed tomographic angiography.
J Emerg Med. 2011 Apr ; 40 (4): 469-75

Sheikh SI, Singhal AB
Extension of "roller coaster dissection" after tissue plasminogen activator.
AJNR Am J Neuroradiol. 2010 Jan ; 31 (1): E4

Maas MB, Furie KL, Lev MH, Ay H, Singhal AB, Greer DM, Harris GJ, Halpern E, Koroshetz WJ, Smith WS
National Institutes of Health Stroke Scale score is poorly predictive of proximal occlusion in acute cerebral ischemia.
Stroke. 2009 Sep ; 40 (9): 2988-93

Fujiwara N, Murata Y, Arai K, Egi Y, Lu J, Wu O, Singhal AB, Lo EH
Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke.
BMC Neurosci. 2009 ; 10 (): 79

Maas MB, Lev MH, Ay H, Singhal AB, Greer DM, Smith WS, Harris GJ, Halpern E, Kemmling A, Koroshetz WJ, Furie KL
Collateral vessels on CT angiography predict outcome in acute ischemic stroke.
Stroke. 2009 Sep ; 40 (9): 3001-5

Saver JL, Albers GW, Dunn B, Johnston KC, Fisher M,
Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials.
Stroke. 2009 Jul ; 40 (7): 2594-600

Wu O, Sorensen AG, Benner T, Singhal AB, Furie KL, Greer DM
Comatose patients with cardiac arrest: predicting clinical outcome with diffusion-weighted MR imaging.
Radiology. 2009 Jul ; 252 (1): 173-81

Arsava EM, Rahman R, Rosand J, Lu J, Smith EE, Rost NS, Singhal AB, Lev MH, Furie KL, Koroshetz WJ, Sorensen AG, Ay H
Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke.
Neurology. 2009 Apr 21; 72 (16): 1403-10

Latorre JG, Chou SH, Nogueira RG, Singhal AB, Carter BS, Ogilvy CS, Rordorf GA
Effective glycemic control with aggressive hyperglycemia management is associated with improved outcome in aneurysmal subarachnoid hemorrhage.
Stroke. 2009 May ; 40 (5): 1644-52

Singhal AB, Kimberly WT, Schaefer PW, Hedley-Whyte ET
Case records of the Massachusetts General Hospital. Case 8-2009. A 36-year-old woman with headache, hypertension, and seizure 2 weeks post partum.
N Engl J Med. 2009 Mar 12; 360 (11): 1126-37

Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH,
Update of the stroke therapy academic industry roundtable preclinical recommendations.
Stroke. 2009 Jun ; 40 (6): 2244-50

Goldmakher GV, Camargo EC, Furie KL, Singhal AB, Roccatagliata L, Halpern EF, Chou MJ, Biagini T, Smith WS, Harris GJ, Dillon WP, Gonzalez RG, Koroshetz WJ, Lev MH
Hyperdense basilar artery sign on unenhanced CT predicts thrombus and outcome in acute posterior circulation stroke.
Stroke. 2009 Jan ; 40 (1): 134-9

Ay H, Arsava EM, Gungor L, Greer D, Singhal AB, Furie KL, Koroshetz WJ, Sorensen AG
Admission international normalized ratio and acute infarct volume in ischemic stroke.
Ann Neurol. 2008 Nov ; 64 (5): 499-506

Molloy ES, Singhal AB, Calabrese LH
Tumour-like mass lesion: an under-recognised presentation of primary angiitis of the central nervous system.
Ann Rheum Dis. 2008 Dec ; 67 (12): 1732-5

Ay H, Arsava EM, Rosand J, Furie KL, Singhal AB, Schaefer PW, Wu O, Gonzalez RG, Koroshetz WJ, Sorensen AG
Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke.
Stroke. 2008 May ; 39 (5): 1409-13

Mintzopoulos D, Khanicheh A, Konstas AA, Astrakas LG, Singhal AB, Moskowitz MA, Rosen BR, Tzika AA
Functional MRI of Rehabilitation in Chronic Stroke Patients Using Novel MR-Compatible Hand Robots.
Open Neuroimag J. 2008 ; 2 (): 94-101

Singhal AB, Lo EH
Advances in Emerging Nondrug Therapies for Acute Stroke 2007.
Stroke. 2008 Jan 10; ():

Calabrese LH, Molloy ES, Singhal AB
Primary central nervous system vasculitis: progress and questions.
Ann Neurol. 2007 Nov ; 62 (5): 430-2

Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG
A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System.
Stroke. 2007 Nov ; 38 (11): 2979-84

Singhal AB, Ratai E, Benner T, Vangel M, Lee V, Koroshetz WJ, Schaefer PW, Sorensen AG, Gonzalez RG
Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke.
Stroke. 2007 Oct ; 38 (10): 2851-4

Schaefer PW, Miller JC, Singhal AB, Thrall JH, Lee SI
Headache: when is neurologic imaging indicated?
J Am Coll Radiol. 2007 Aug ; 4 (8): 566-9

Camargo EC, Furie KL, Singhal AB, Roccatagliata L, Cunnane ME, Halpern EF, Harris GJ, Smith WS, Gonzalez RG, Koroshetz WJ, Lev MH
Acute brain infarct: detection and delineation with CT angiographic source images versus nonenhanced CT scans.
Radiology. 2007 Aug ; 244 (2): 541-8

Rosenbloom MH, Singhal AB
CT angiography and diffusion-perfusion MR imaging in a patient with ipsilateral reversible cerebral vasoconstriction after carotid endarterectomy.
AJNR Am J Neuroradiol. 2007 May ; 28 (5): 920-2

Muehlschlegel S, Voetsch B, Singhal AB
CT angiography and CT perfusion in post-CEA hyperperfusion syndrome.
Neurology. 2007 Apr 24; 68 (17): 1437

Singhal AB
A review of oxygen therapy in ischemic stroke.
Neurol Res. 2007 Mar ; 29 (2): 173-83

Chou SH, Singhal AB
Multiple punctate cerebral hemorrhages in acute leukemia with blast crisis.
Neurology. 2007 Mar 20; 68 (12): 953

Katzin LW, Levine M, Singhal AB
Dural puncture headache, postpartum angiopathy, pre-eclampsia and cortical vein thrombosis after an uncomplicated pregnancy.
Cephalalgia. 2007 May ; 27 (5): 461-4

Calabrese LH, Dodick DW, Schwedt TJ, Singhal AB
Narrative review: reversible cerebral vasoconstriction syndromes.
Ann Intern Med. 2007 Jan 2; 146 (1): 34-44

Menezes NM, Ay H, Wang Zhu M, Lopez CJ, Singhal AB, Karonen JO, Aronen HJ, Liu Y, Nuutinen J, Koroshetz WJ, Sorensen AG
The real estate factor: quantifying the impact of infarct location on stroke severity.
Stroke. 2007 Jan ; 38 (1): 194-7

Galpern WR, Singhal AB
Neuroprotection: lessons from a spectrum of neurological disorders.
Int J Stroke. 2006 May ; 1 (2): 97-9

Singhal AB
Oxygen therapy in stroke: past, present, and future.
Int J Stroke. 2006 Nov ; 1 (4): 191-200

Topcuoglu MA, Singhal AB
Effects of common medications on cerebral vasospasm after subarachnoid haemorrhage.
Expert Opin Drug Saf. 2006 Jan ; 5 (1): 57-65

Singhal AB, Lo EH, Dalkara T, Moskowitz MA
Advances in stroke neuroprotection: hyperoxia and beyond.
Neuroimaging Clin N Am. 2005 Aug ; 15 (3): 697-720, xii-xiii

Singhal AB, Bernstein RA
Postpartum angiopathy and other cerebral vasoconstriction syndromes.
Neurocrit Care. 2005 ; 3 (1): 91-7

Badjatia N, Topcuoglu MA, Buonanno FS, Smith EE, Nogueira RG, Rordorf GA, Carter BS, Ogilvy CS, Singhal AB
Relationship between hyperglycemia and symptomatic vasospasm after subarachnoid hemorrhage.
Crit Care Med. 2005 Jul ; 33 (7): 1603-9; quiz 1623

Kim HY, Singhal AB, Lo EH
Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia.
Ann Neurol. 2005 Apr ; 57 (4): 571-5

Singhal AB, Topcuoglu MA, Dorer DJ, Ogilvy CS, Carter BS, Koroshetz WJ
SSRI and statin use increases the risk for vasospasm after subarachnoid hemorrhage.
Neurology. 2005 Mar 22; 64 (6): 1008-13

Singhal AB, Benner T, Roccatagliata L, Koroshetz WJ, Schaefer PW, Lo EH, Buonanno FS, Gonzalez RG, Sorensen AG
A pilot study of normobaric oxygen therapy in acute ischemic stroke.
Stroke. 2005 Apr ; 36 (4): 797-802

Doss-Esper CE, Singhal AB, Smith MS, Henderson GV
Reversible posterior leukoencephalopathy, cerebral vasoconstriction, and strokes after intravenous immune globulin therapy in guillain-barre syndrome.
J Neuroimaging. 2005 Apr ; 15 (2): 188-92

Hoh BL, Topcuoglu MA, Singhal AB, Pryor JC, Rabinov JD, Rordorf GA, Carter BS, Ogilvy CS
Effect of clipping, craniotomy, or intravascular coiling on cerebral vasospasm and patient outcome after aneurysmal subarachnoid hemorrhage.
Neurosurgery. 2004 Oct ; 55 (4): 779-86; discussion 786-9

Smith EE, Fitzsimmons AL, Nogueira RG, Singhal AB
Spontaneous hyperacute postischemic hemorrhage leading to death.
J Neuroimaging. 2004 Oct ; 14 (4): 361-4

Singhal AB
Cerebral vasoconstriction syndromes.
Top Stroke Rehabil. 2004 ; 11 (2): 1-6

Singhal AB
Postpartum angiopathy with reversible posterior leukoencephalopathy.
Arch Neurol. 2004 Mar ; 61 (3): 411-6

Zhang JH, Singhal AB, Toole JF
Oxygen therapy in ischemic stroke.
Stroke. 2003 Sep ; 34 (9): e152-3; author reply e153-5

Topcuoglu MA, Ogilvy CS, Carter BS, Buonanno FS, Koroshetz WJ, Singhal AB
Subarachnoid hemorrhage without evident cause on initial angiography studies: diagnostic yield of subsequent angiography and other neuroimaging tests.
J Neurosurg. 2003 Jun ; 98 (6): 1235-40

Singhal AB, Newstein MC, Budzik R, Cha JH, Rordorf G, Buonanno FS, Panzara MA
Diffusion-weighted magnetic resonance imaging abnormalities in Bartonella encephalopathy.
J Neuroimaging. 2003 Jan ; 13 (1): 79-82

Dijkhuizen RM, Singhal AB, Mandeville JB, Wu O, Halpern EF, Finklestein SP, Rosen BR, Lo EH
Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study.
J Neurosci. 2003 Jan 15; 23 (2): 510-7

Singhal AB, Wang X, Sumii T, Mori T, Lo EH
Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion.
J Cereb Blood Flow Metab. 2002 Jul ; 22 (7): 861-8

Singhal AB
Thunderclap headache, reversible cerebral arterial vasoconstriction, and unruptured aneurysms.
J Neurol Neurosurg Psychiatry. 2002 Jul ; 73 (1): 96; author reply 96-7

Singhal AB, Topcuoglu MA, Buonanno FS
Acute ischemic stroke patterns in infective and nonbacterial thrombotic endocarditis: a diffusion-weighted magnetic resonance imaging study.
Stroke. 2002 May ; 33 (5): 1267-73

Singhal AB, Topcuoglu MA, Koroshetz WJ
Diffusion MRI in three types of anoxic encephalopathy.
J Neurol Sci. 2002 Apr 15; 196 (1-2): 37-40

Mori T, Wang X, Jung JC, Sumii T, Singhal AB, Fini ME, Dixon CE, Alessandrini A, Lo EH
Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects.
J Cereb Blood Flow Metab. 2002 Apr ; 22 (4): 444-52

Singhal AB, Dijkhuizen RM, Rosen BR, Lo EH
Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke.
Neurology. 2002 Mar 26; 58 (6): 945-52

Singhal AB, Caviness VS, Begleiter AF, Mark EJ, Rordorf G, Koroshetz WJ
Cerebral vasoconstriction and stroke after use of serotonergic drugs.
Neurology. 2002 Jan 8; 58 (1): 130-3

Lo EH, Singhal AB, Torchilin VP, Abbott NJ
Drug delivery to damaged brain.
Brain Res Brain Res Rev. 2001 Dec ; 38 (1-2): 140-8

Singhal AB, Singhal BS, Ursekar MA, Koroshetz WJ
Serial MR angiography and contrast-enhanced MRI in chickenpox-associated stroke.
Neurology. 2001 Mar 27; 56 (6): 815-7

Sumii T, Singhal AB, Asahi M, Shimizu-Sasamata M, Suzuki M, Miyata K, Lo EH
Protective effects of pamiteplase, a modified t-PA, in a rat model of embolic stroke.
Neuroreport. 2001 Mar 5; 12 (3): 615-8

Singhal AB, Buonanno F, Rordorf G
Cerebral venous sinus thrombosis associated with hepatic cirrhosis.
J Neurol Sci. 1999 Dec 1; 171 (1): 65-8

Singhal AB, Drago S, Sheth SG, Chowgule BR, Nabar ST
Ruptured type III cervical spinal cord arteriovenous malformation as a cause of acute quadriparesis.
J Assoc Physicians India. 1995 Aug ; 43 (8): 565-6

Shpitz B, Chambers CA, Singhal AB, Hozumi N, Fernandes BJ, Roifman CM, Weiner LM, Roder JC, Gallinger S
High level functional engraftment of severe combined immunodeficient mice with human peripheral blood lymphocytes following pretreatment with radiation and anti-asialo GM1.
J Immunol Methods. 1994 Feb 28; 169 (1): 1-15

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Educational Video

Still from the Stroke Evaluation simulation

This video simulation of an Emergency stroke evaluation illustrates the care of patients with acute stroke by the MGH Acute Stroke team.